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Cooperative Threat Reduction (CTR) in today's world must address the complex challenges posed by weapons of mass destruction (WMD) to national security and global stability. Effective CTR requires a network of diverse stakeholders to secure WMD-related materials, technologies, and knowledge; prevent their misuse; and reduce or mitigate the risks caused by their availability.

How do U.S. CTR programs and initiatives need to adapt to continue to be effective in the 21st century? How should the United States work to engage key partners in CTR? What steps can the United States take to globally build awareness and capacity to prevent the proliferation of WMD-related materials, technologies, and knowledge?